Glaucoma severity linked with steroid-induced ocular hypertension
Key takeaways:
- Sufferers with extreme glaucoma have been extra more likely to expertise steroid-induced ocular hypertension.
- Steroid response was additionally greater in these with earlier glaucoma surgical procedures or on extra preop medicines.
KIAWAH ISLAND, S.C. — Sufferers with worse glaucoma severity have been extra more likely to expertise steroid-induced ocular hypertension, based on a examine introduced at Kiawah Eye 2025.
R. Bryce Robbins, MD, mentioned spikes in IOP are necessary to contemplate in sufferers who lately underwent a minimally invasive glaucoma process.
“Some early research prompt that roughly one out of eight sufferers have a steroid response in some MIGS [procedures],” he mentioned. “Extra research are wanted to find out each the medical and demographic predictors of steroid response, significantly in our glaucoma affected person inhabitants.”
Robbins and colleagues performed a retrospective chart evaluate of 143 eyes from 101 sufferers who underwent angle-based MIGS.
Thirty-three sufferers have been categorized at steroid responders and skilled a rise in IOP of not less than 5 mm Hg from baseline throughout steroid use with out one other trigger that resolved after tapering.
Within the steroid responder group, 45.5% of sufferers had extreme glaucoma (P = .01). Sufferers with a better variety of prior glaucoma surgical procedures or who have been on extra preoperative glaucoma medicine courses had a better likelihood of being within the steroid responder group (P = .03 and P = .008, respectively).
Sufferers with decrease visible discipline imply deviation scores and decrease common retinal nerve fiber layer thickness have been additionally extra more likely to be within the steroid responder group (P = .003 and P = .006, respectively).
There was no distinction in steroid response between totally different MIGS procedures, based on Robbins.
“We did not see a distinction within the charges of secondary surgical interventions between steroid responders and non-responders,” he mentioned.
Sources/Disclosures
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Robbins RB, et al. Predictors of steroid-induced ocular hypertension. Offered at: Kiawah Eye; Could 29-31, 2025; Kiawah Island, South Carolina.
Disclosures:
Robbins stories no related monetary disclosures.
