Summit Therapeutics hits doable snag on lung most cancers drug seen as blockbuster

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Adam Feuerstein is a senior author and biotech columnist, reporting on the crossroads of drug improvement, enterprise, Wall Road, and biotechnology. He’s additionally a co-host of the weekly biotech podcast The Readout Loud and writer of the publication Adam’s Biotech Scorecard. You may attain Adam on Sign at stataf.54.

Summit Therapeutics could have a geography drawback with its lung most cancers drug ivonescimab.

In a examine replace reported Sunday, sufferers from North America and Europe handled with the drug noticed their lung most cancers return and progress quicker than sufferers from China — a discordant end result that might complicate Summit’s plans to safe approval of ivonescimab within the U.S. and Europe.

The chance of tumor development fell by 45% for members from China handled with ivonescimab and chemotherapy in comparison with chemotherapy and a placebo. For members from Western international locations, nonetheless, the chance of tumor development was diminished by 33% — an consequence that failed to achieve statistical significance. 

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